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Vitamin D and SARS-CoV-2 virus/COVID-19 disease
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  • Published on:
    Existing meta-analysis of serum vitamin D and pulmonary function across nine population-based cohort studies contributes to the evidence base on vitamin D and respiratory health
    • Jiayi Xu, Postdoctoral Fellow Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai
    • Other Contributors:
      • Dana B. Hancock, Senior Genetic Epidemiologist & Director
      • Patricia A. Cassano, Professor & Director

    Lanham-New et al. reviewed current evidence of vitamin D associations with health conditions that are pertinent to SARS-CoV-2 virus/COVID-19 disease. Their review highlighted the importance of a well-balanced diet, including an adequate amount of vitamin D intake, to boost the immune system and to resist viral infection. Lanham-New et al. also noted positive associations reported in a single study between the blood metabolite 25-hydroxyvitamin D (25OHD) and lung function and noted that “formal systematic reviews/meta-analyses of these associations are urgently required.” We would like to draw attention to several published reports of observational cohort studies evaluating the association of serum 25OHD with lung function (1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18) and to our meta-analysis that investigated this association across nine large population-based cohort studies (total N=27,128) (19).
    Our cross-ancestry meta-analysis included adults (age range: 19-95 yrs) living in northern latitudes (e.g. the Netherlands, Iceland, northern part of U.S.) and adults with darker skin tones (i.e., African ancestry participants), who may be at greater risk of vitamin D deficiency given limited sun exposure or slower production of vitamin D in the skin. Prior to combining association results for meta-analysis, the lung function outcomes, exposure (25OHD), and the covariates were harmonized, and the same statistical models were applied across the nine coh...

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    Conflict of Interest:
    None declared.
  • Published on:
    POPULATION RESILIENCE We all need optimal back ground immunity, ahead of a second Covid-19 wave
    • Helga M Rhein, retired general practitioner previously Sighthill Health Centre, 380 Calder Road, Edinburgh EH11 4AU

    POPULATION RESILIENCE

    We all need optimal back ground immunity, ahead of a second Covid-19 wave

    In your report (1) you mention the value of sufficient vitamin D for a healthy immune system. You are missing out, however, that the immune function and regulation of appropriate genes and enzymes need a higher vitamin D level (25(OH)D), higher than 25 nmol/l (2-5), as does maximal PTH suppression (6) and is the physiological blood levels in outdoor living people (7). All advocate the optimal blood level to be above 75 nmol/l. An extensive evidence collection is maintained on a specified website (8), and improvements in many conditions have been shown when blood levels were higher (osteomalacia (9), heart disease (10), respiratory tract infections (11), depression (12), COPD (13), cancer survival (14-17) and many more), resulting in the worldwide consensus that levels should be higher than 25 nmol/l. A group of 48 scientists has also published a consensus statement in 2015 that a level of 100 nmol/l should be called sufficient (18). To reach such a level from an average UK level (approx 40 nmol/l) one needs much higher doses of vitamin D than 10 mcg (400 IU).

    But your report says a blood level of 25 nmol/l is sufficient and the majority would only need 10 mcg of a D-supplement.
    However, the Institute of Medicine in the US has declared the level of sufficiency as 50 nmol/l, and they advise also higher D-supplement intake. In contrast to the UK where suf...

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    Conflict of Interest:
    None declared.
  • Published on:
    A call for randomized controlled clinical trial, not dismissal, is warranted

    Multiple lines of strong circumstantial arguments supporting the putative role of Vitamin D as candidate pandemic mitigation agents have been made based on unbiased genomics-guided tracing of SARS-CoV-2 targets in human cells which generated some quite unexpected findings. The title of the paper reporting observations is “Tripartite combination of candidate pandemic mitigation agents: Vitamin D, Quercetin, and Estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 pandemic defined by the genomics-guided tracing of SARS-CoV-2 targets in human cells”. One of the end points of this contribution is the identification of the tripartite combination of candidate pandemic mitigation agents comprising of Vitamin D/Quercetin/Estradiol. After the completion of the genomics screens, it was really quite unexpected conclusion to reach. However, after the follow-up analyses of available experimental and clinical observations it seems to make more sense. Please see the link below to the paper

    https://doi.org/10.3390/biomedicines8050129

    One of the main conclusions of the paper is that the randomized controlled clinical trial should be conducted to assess the potential clinical efficacy of the tripartite combination.

    Best regards,

    Dr. Gennadi V. Glinsky, MD, Ph.D.
    Correspondence: gglinskii@ucsd.edu
    Web:...

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    Conflict of Interest:
    None declared.