More information about text formats
This study seems to support the growing evidence that hangovers are largely related to oxidative stress, and perhaps to large extent the increased activity of acetaldehyde. However, it is difficult to make much sense out of the data when the actual amounts of each component have not been presented. Thiamine for example, included in the vitamin and minerals group, is a potent antioxidant that has been shown to reduce the mortality of rats poisoned with acetaldehyde. Were sufficient amounts of thiamine included? Other potent antioxidants that have been shown to reduce acetaldehyde poisoning in rats and to reduce symptoms of hangover include L-cysteine. This nutrient plays a role in the generation of glutathione, the inactivation of acetaldehyde, and the protection against damage due to oxidative stress. The significance of the current manuscript without information on L-cysteine or glutathione is therefore limited.
Conflict of Interest
Our company manufactures a hangover treatment which contains thiamine and L-cysteine and have published a clinical trial in (ClinTrials Res 2018) that reported efficacy in hangover. This was not cited in the current paper.