You are here

  • Home
  • Online First
  • Enhanced long-term dietary change and adherence in a nutrigenomics-guided lifestyle intervention compared to a population-based (GLB/DPP) lifestyle intervention for weight management: results from the NOW randomised controlled trial

Article Text

Article menu

other Versions

Download PDFPDF

XML
Original research
Enhanced long-term dietary change and adherence in a nutrigenomics-guided lifestyle intervention compared to a population-based (GLB/DPP) lifestyle intervention for weight management: results from the NOW randomised controlled trial
  1. Justine Horne1,2,
  2. Jason Gilliland3,4,5,6,7,8,
  3. Colleen O'Connor7,9,
  4. Jamie Seabrook3,6,7,8,9 and
  5. Janet Madill7,9
  1. 1East Elgin Family Health Team, Aylmer, Ontario, Canada
  2. 2Health and Rehabilitation Sciences, Western University, London, Ontario, Canada
  3. 3Department of Paediatrics, Western University, London, Ontario, Canada
  4. 4School of Health Studies, Western University, London, Ontario, Canada
  5. 5Department of Geography, Western University, London, Ontario, Canada
  6. 6Children's Health Research Institute, London, Ontario, Canada
  7. 7Lawson Health Research Institute, London, Ontario, Canada
  8. 8Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada
  9. 9School of Food and Nutritional Sciences, Brescia University College (Western University), London, Ontario, Canada
  1. Correspondence to Dr Justine Horne, Western University, London, N6A 3K7, Canada; jhorne5{at}uwo.ca

Abstract

Background Adherence to nutritional guidelines for chronic disease prevention and management remains a challenge in clinical practice. Innovative strategies are needed to help optimise dietary behaviour change.

Objective The objective of this study was to determine if a nutrigenomics-guided lifestyle intervention programme could be used to motivate greater dietary adherence and change in dietary intake short-term, moderate-term and long-term compared to the gold-standard population-based weight management intervention (Group Lifestyle Balance (GLB)/Diabetes Prevention Programme (DPP)).

Design The Nutrigenomics, Overweight/Obesity, and Weight Management (NOW) randomised controlled trial is a pragmatic, parallel-group, superiority clinical trial (n=140), which was conducted at the East Elgin Family Health Team (EEFHT). GLB weight management groups were prerandomised 1:1 to receive either the standard GLB programme or a modified GLB+nutrigenomics (GLB+NGx) programme. Three 24-hour recalls were collected at baseline, 3, 6 and 12 months using the validated multiple pass method. Research assistants collecting the three 24-hour recalls were blinded to the participants’ group assignments. Statistical analyses included split plot analyses of variance (ANOVAs), two-way ANOVAs, binary logistic regression, χ2 and Fisher’s exact tests. Using the Theory of Planned Behaviour as guidance, key confounding factors of behaviour change were considered in the analyses. This study was registered with clinicaltrials.gov (NCT03015012).

Results Only the GLB+NGx group significantly reduced their total fat intake from baseline to 12-month follow-up (from 36.0%±4.8% kcal to 30.2%±8.7% kcal, p=0.02). Long-term dietary adherence to total fat and saturated fat guidelines was also significantly (p<0.05) greater in the GLB+NGx group compared to the standard GLB group.

Conclusions Weight management interventions guided by nutrigenomics can motivate long-term improvements in dietary fat intake above and beyond gold-standard population-based interventions.

  • precision nutrition
  • nutrition assessment
  • weight management
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjnph-2020-000073

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Twitter @justinehorneRD, @westernprof, @bresciaprof, @Jamie_Seabrook1

    • Contributors All authors (JH, JG, JS, CO and JM) were involved in designing the study. JH conducted the study at the East Elgin Family Health Team, wrote the first manuscript draft and revised subsequent drafts. JH and JS completed the statistical analyses. All authors (JH, JG, JS, CO and JM) revised manuscript drafts and approved the final manuscript.

    • Funding This project was supported by a grant from Brescia University College. Nutrigenomix provided complimentary genetic test kits and laboratory analysis. JH was supported through an Ontario Graduate Scholarship, Ontario Respiratory Care Society Fellowship, and Canadian Institutes of Health Research Frederick Banting and Charles Best Doctoral Award.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval This study was approved by the Western University Research Ethics Board and registered with clinicaltrials.gov (NCT03015012).

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available on reasonable request. Please contact the corresponding author with any requests.