other Versions

No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests


  • A rapid response is a moderated but not peer reviewed online response to a published article in a BMJ journal; it will not receive a DOI and will not be indexed unless it is also republished as a Letter, Correspondence or as other content. Find out more about rapid responses.
  • We intend to post all responses which are approved by the Editor, within 14 days (BMJ Journals) or 24 hours (The BMJ), however timeframes cannot be guaranteed. Responses must comply with our requirements and should contribute substantially to the topic, but it is at our absolute discretion whether we publish a response, and we reserve the right to edit or remove responses before and after publication and also republish some or all in other BMJ publications, including third party local editions in other countries and languages
  • Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future.
  • By submitting this rapid response you are agreeing to our terms and conditions for rapid responses and understand that your personal data will be processed in accordance with those terms and our privacy notice.
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    Small differences = no effects

    The authors report data on genetically determined Vitamin D levels and their association with SARS-CoV-2 infection and severe COVID-19 courses. They conclude: "In conclusion, we found no evidence that vitamin D is protective against SARS-CoV-2 infection or COVID-19 severity. "

    The main problem of this analysis from GWAS data is, that the observed difference between Vitamin D-levels in quartile 1 (45,6 nmol/l = 18 ng/ml) and quartile 4 (54,0 nmol/l = 21,6 ng/ml) is so small, that no one would it expect to have an effect on the predefined endpoints.

    In order to achieve optimum immune responses, a Vitamin D-level of at least 75 nmol/l, preferably >100 nmol/l would be required.
    So, as much as this study seems to give an evidence-based conclusion, it is not helpful at all to answer important questions for clinicians:

    1) Does Vitamin D-supplementation to achieve OPTIMUM Vitamin D levels reduce the likelihood of SARS-CoV-2 infection?

    2) Does a high-dose vitamin D therapy (like 3x 40 000 IU in week 1) in early SARS-CoV-2 infection prevent severe courses of COVID-19, as it was suggested by the randomised intervention study by Castillo et al.

    From a clinician’s standpoint, to me it seems clear, that all people should be advised to treat a Vitamin D deficiency of < 75 nmol/l or 30 ng/ml, as there are virtually no risks of Vitamin D supplementation, and possibly many benefits in this Pandemic situation, especially in the immunoc...

    Show More
    Conflict of Interest:
    None declared.