RT Journal Article
SR Electronic
T1 Genetic factors associated with obesity risks in a Kazakhstani population
JF BMJ Nutrition, Prevention & Health
JO BMJ Nutrition
FD BMJ Publishing Group Ltd
SP bmjnph-2020-000139
DO 10.1136/bmjnph-2020-000139
A1 Madina Razbekova
A1 Alpamys Issanov
A1 Mei-Yen Chan
A1 Robbie Chan
A1 Dauren Yerezhepov
A1 Ulan Kozhamkulov
A1 Ainur Akilzhanova
A1 Chee-Kai Chan
YR 2021
UL http://nutrition.bmj.com/content/early/2021/02/05/bmjnph-2020-000139.abstract
AB Objectives There is limited published literature on the genetic risks of chronic inflammatory related disease (eg, obesity and cardiovascular disease) among the Central Asia population. The aim is to determine potential genetic loci as risk factors for obesity for the Kazakhstani population.Setting Kazakhstan.Participants One hundred and sixty-three Kazakhstani nationals (ethnic groups: both Russians and Kazakhs) were recruited for the cross-sectional study. Linear regression models, adjusted for confounding factors, were used to examine the genetic associations of single nucleotide polymorphisms (SNPs) in 19 genetic loci with obesity (73 obese/overweight individuals and 90 controls).Results Overall, logistic regression analyses revealed genotypes C/T in CRP (rs1205), A/C in AGTR1 (rs5186), A/G in CBS (rs234706), G/G in FUT2 (rs602662), A/G in PAI-1 (rs1799889), G/T (rs1801131) and A/G (rs1801133) in MTHFR genes significantly decrease risk of overweight/obesity. After stratification for ethnicity, rs234706 was significantly associated with overweight/obesity in both Russians and Kazakhs, while rs1800871 was significant in Kazakhs only.Conclusions This study revealed that variations in SNPs known to be associated with cardiovascular health can also contribute to the risks of developing obesity in the population of Kazakhstan.