RT Journal Article
SR Electronic
T1 Reduced COVID-19 severity elicited by weight loss from a medically supervised ketogenic diet in a geographically diverse ambulatory population with type 2 diabetes and obesity
JF BMJ Nutrition, Prevention & Health
JO BMJ Nutrition
FD BMJ Publishing Group Ltd
SP 154
OP 158
DO 10.1136/bmjnph-2022-000444
VO 5
IS 2
A1 Volk, Brittanie M
A1 Roberts, Caroline G P
A1 VanTieghem, Michelle
A1 George, M Patricia
A1 Adams, Rebecca N
A1 Athinarayanan, Shaminie J
A1 McKenzie, Amy L
YR 2022
UL http://nutrition.bmj.com/content/5/2/154.abstract
AB Objective To investigate factors associated with COVID-19 severity in ambulatory individuals with type 2 diabetes mellitus (T2DM) and obesity treated with a medically supervised ketogenic diet (MSKD).Research design and methods In this real-world, retrospective, exploratory analysis, multivariate modelling was used to assess clinical factors associated with hospitalisation for COVID-19 in a geographically diverse outpatient population with T2DM treated virtually.Results Leading up to COVID-19 onset, non-hospitalised patients had higher average ketones (0.64 vs 0.52 mmol/L; p=0.016) and greater weight loss (6.8% vs 4.2%; p=0.009) compared with those hospitalised. Greater weight loss was significantly associated with lower likelihood of hospitalisation (adjusted OR=0.91, p=0.005), controlling for enrolment demographics and medical characteristics.Conclusions Therapies such as MSKD, which elicit rapid, significant weight loss, may favourably impact COVID-19 hospitalisation rate and severity in individuals with T2DM and obesity.Data are available upon reasonable request.