RT Journal Article SR Electronic T1 Moderate-to-severe household food insecurity is associated with depression among adolescent girls in northern Ghana: a cross-sectional analysis JF BMJ Nutrition, Prevention & Health JO BMJ Nutrition FD BMJ Publishing Group Ltd SP e000523 DO 10.1136/bmjnph-2022-000523 A1 Fusta Azupogo A1 Nawaf Saeed A1 Anthony Wemakor A1 Hammond Yaw Addae A1 Michael Boah A1 Inge D Brouwer YR 2023 UL http://nutrition.bmj.com/content/early/2023/01/02/bmjnph-2022-000523.abstract AB Objective Household food insecurity is positively associated with depression; however, the association among adolescents is not well known. We examined the association between household food insecurity and depression among adolescent girls in Northern Ghana.Methods We analysed data from the Ten2Twenty-Ghana randomised controlled trial end-line for adolescent girls aged 10–17 years (n=582). The girls were chosen at random from 19 primary schools in the Mion District of Ghana’s northern region. The children’s depression inventory and the Food Insecurity Experience Scale were used in face-to-face interviews to assess depression and household food insecurity. Hierarchical survey binary logistic regression and linear mixed models were used to examine the association between household food insecurity and depressive symptoms. We took into account a number of potential confounders in the analysis, such as life satisfaction, self-efficacy, self-esteem, health complaints, child’s age, menarche status, pubertal development, anaemia, stunting, frequency of consuming fruits and vegetables, frequency of consuming animal-sourced foods, maternal age, household wealth index and size, and the intervention group the girl was assigned to in the trial.Results About 20.1% of adolescent girls were classified as likely depressed, and 70.3% of their households were food insecure, with 22.9% and 18.0% being moderately and severely food insecure, respectively. Compared with girls from food-secure households, those from moderately (adjusted OR (AOR) 2.63, 95% CI (1.35 to 5.12)) and severely (AOR 3.28, 95% CI (1.66 to 6.49)) food insecure households had about three times the odds of being classified as depressed, after controlling for potential confounders. The odds of being likely depressed were about twice for adolescent girls from food-insecure households compared with their peers from food-secure households in both the crude and final adjusted model.Conclusion The study discovered high levels of household food insecurity and depression in adolescent girls in Northern Ghana, with a dose-response association between the two.Data are available on reasonable request from the corresponding author.