Associations between neighbourhood variables and BMI, by quintile of genetic risk based on 91-SNP and 69-SNP GRSs
| 91-SNP GRS | 69-SNP GRS | |||||
| Quintile of genetic risk | Mean BMI difference for unit increase in neighbourhood exposure | P for interaction | Quintile of genetic risk | Mean BMI difference for unit increase in neighbourhood exposure | P for interaction | |
| Fast-food proximity*† (unit change = 10-fold increase in distance (m) to nearest fast-food outlet) | Q1 | −0.081 (−0.213 to 0.052) | 0.028 | Q1 | −0.080 (−0.214 to 0.055) | 0.018 |
| Q2 | −0.115 (−0.239 to 0.009) | Q2 | −0.117 (−0.243 to 0.009) | |||
| Q3 | −0.137 (−0.259 to −0.014) | Q3 | −0.140 (−0.264 to −0.017) | |||
| Q4 | −0.158 (−0.282 to −0.035) | Q4 | −0.164 (−0.289 to −0.039) | |||
| Q5 | −0.194 (−0.326 to −0.062) | Q5 | −0.204 (−0.337 to −0.070) | |||
| Availability of PA facilities*‡ (unit change = one additional facility) | Q1 | −0.074 (−0.100 to −0.047) | 0.530 | Q1 | −0.070 (−0.097 to −0.044) | 0.178 |
| Q2 | −0.075 (−0.101 to −0.049) | Q2 | −0.074 (−0.099 to −0.048) | |||
| Q3 | −0.076 (−0.101 to −0.050) | Q3 | −0.076 (−0.101 to −0.050) | |||
| Q4 | −0.077 (−0.103 to −0.051) | Q4 | −0.078 (−0.103 to −0.052) | |||
| Q5 | −0.078 (−0.105 to −0.052) | Q5 | −0.081 (−0.106 to −0.054) | |||
*Regression models were adjusted for age (years), sex (male/female), highest education level attained (degree; A level or equivalent; O level/GCSE or equivalent; CSE or equivalent; NVQ/HND/HNC; other professional qualification; none of the above), annual household income (<£18 000; £18,000–£30 999; £31000–£51 999; £52 000–£100 000; >£100 000), employment status (paid work, retired, unable to work, unemployed, other), area deprivation (Townsend score), urbanicity (urban/non-urban), neighbourhood residential density (count of residential features within a 1 km street network buffer of home address, log transformed).
†Also adjusted for availability of PA facilities.
‡Also adjusted for fast-food proximity.
BMI, body mass index; CSE, Certificate of Secondary Education; GRS, genetic risk score; HNC, Higher National Certificate; HND, Higher National Diploma; NVQ, National Vocational Qualification; PA, physical activity; SNP, single-nucleotide polymorphism.