OR (95% CI) | P value | |
Evidence assessment units concluding a neutral effect or association of LES on BW (n=7) | ||
Main message of cited articles | ||
Neutral (no directional effect or association) | 1 (ref) | |
Unable to draw a conclusion from the article | 1.67 (1.07 to 2.54) | 0.03 |
Cited article type | ||
Systematic review with meta-analysis | 1 (ref) | |
Observational study | 1.45 (1.06 to 2.02) | 0.03 |
Evidence assessment units concluding insufficient evidence to draw a conclusion about the effect of LES on BW (n=26) | ||
Cited article type | ||
Systematic review with meta-analysis | 1 (ref) | |
Systematic review without meta-analysis | 1.97 (1.12 to 3.45) | 0.02 |
Cited article population | ||
Adults | 1 (ref) | |
Children | 1.84 (1.43 to 2.37) | <0.001 |
Cited article journal impact factor, current (2018)* | 1.10 (1.00 to 1.20) | 0.049 |
Systematic reviews (evidence assessment units) without meta-analysis (n=14) | ||
Cited article type | ||
Systematic review with meta-analysis | 1 (ref) | |
Randomised controlled trial | 0.61 (0.38 to 1.00) | 0.04 |
Cited article population | ||
Adults | 1 (ref) | |
Both | 1.86 (1.20 to 2.82) | 0.004 |
Children | 1.66 (1.20 to 2.29) | 0.002 |
Logistic mixed-effects regression. The analysis of neutral reviews is additionally adjusted for overdispersion.
Bold value indicates result is statistically significant with p<0.05 or lower.
*Journal impact factor was base 2 log-transformed, so OR is the change per twofold change in journal impact factor.
BW, body weight; CI, confidence interval; LES, low-energy sweeteners; n, sample size; OR, odds ratio; ref, reference variable.