Author | Outcome | Vitamin D Dose | Vitamin D status (number of studies/participants) | Age (years) | Follow- up (years) | Relative risk (CI 95%) | P-Value | Key findings |
---|---|---|---|---|---|---|---|---|
Weaver et al.2016 | Fracture risk | 400-800IU/day 500-1200mg/day Calcium | Not reported | ≥65 | 1-7 | 0.85(0.73-0.98) | 0.06 | 15% reduction in risk of total fracture. |
Tang et al.2007 | Fracture risk | 800IU/day and 1200mg calcium | †Low (10144)Normal (39167) | 50-85 | 3.5* | 0.88(0.83-0.95) | 0.004 | Calcium with vitamin D associated with a 12% reduction in all fractures.Greater risk reduction with low serum 25(OH)D concentration compared to normal. |
Keum et al. 2019** | Cancer mortality | 400 -2000IU/day 20,000IU/week 500,000IU/Year | 38-83nmol/L | 58-77 | 3-10 | 0.87(0.79-0.96) | 0.005 | 13% reduction in cancer mortality and 7% reduction in cancer incidence over 3–10- year period. |
Han et al.2019 | Cancer mortality | 400IU/day- 500,000IU/year | Not reported | 44-75 | 4.3-28 | 0.81(0.71-0.93) | 0.012 | Dose-response analysis suggests 7% reduction in cancer risk and 2% reduction in cancer mortality with 20nmol/L increment of 25(OH)D. |
Bjelakovic et al. 2014** | All-cause mortality | 300IU/day- 500,000IU/year | <26ng/mL (26) | 18-107 | 0.008-7 | 0.94(0.91-0.98) | 0.002 | 6% decrease in mortality. |
Rejnmark et al. 2012 | All-cause mortality | 300IU/day- 500,000IU/year | Not reported | 53-98 | 3 | 0.91(0.84–0.98) | 0.01 | 7% decrease in mortality. |