Outcome | Effect | 95% CI | P value |
PaO2/FiO2 at day 4 (mean difference, mm Hg) | 38.88 | 10.75 to 67.02 | 0.0068 |
PaO2/FiO2 at day 8 (mean difference, mm Hg) | 23.44 | 1.73 to 45.15 | 0.034 |
Ventilator days (mean difference, days) | −2.24 | −3.77 to −0.71 | 0.0042 |
New organ failure (relative risk) | 0.45 | 0.32 to 0.63 | <0.00001 |
Length of intensive care unit stay (mean difference, days) | −3.09 | −5.19 to −0.99 | 0.004 |
28-day mortality (relative risk) | 0.64 | 0.49 to 0.84 | 0.0015 |
All-cause mortality (relative risk) | 0.79 | 0.59 to 1.07 | Not given |
ARDS, acute respiratory distress syndrome; FiO2, fractional inspired oxygen; PaO2, arterial oxygen tension (or pressure).