Nutrition-related genetic variation among participants in the GLB+NGx group
| Nutrient, Gene (rs number) | Genotype distribution (n, %) | Participants with elevated risk/Enhanced response genotype (n, %) | Associated Risk/Response |
| Calories, UCP1 (rs1800592) | AA (44 to 62.9) AG (19 to 27.1) GG (7 to 10.0) | Elevated risk (26, 37.1) | Lower resting metabolic rate |
| Protein, FTO (rs9939609) | AA (21 to 30.0) TA (27 to 38.6) TT (22 to 31.4) | Enhanced response (21, 30.0) | Weight loss |
| Total fat, TCF7L2 (rs7903146) | TT (6 to 8.6) CT (28 to 40.0) CC (36 to 51.4) | Enhanced response (6, 8.6) | Weight loss |
| SFA, APOA2 (rs5082) | TT (21 to 30.0) TC (44 to 62.9) CC (5 to 7.1) | Enhanced response (5, 7.1) | Weight loss |
| PUFA:SFA, FTO (rs9939609) | AA (21 to 30.0) TA (27 to 38.6) TT (22 to 31.4) | Enhanced response (48, 68.6) | Weight loss |
| MUFA, PPARg2 (rs1801282) | CC (53 to 75.7) CG (17 to 24.3) GG (0 to 0.0) | Enhanced response (17, 24.3) | Weight loss |
| Snacking/Appetite, MC4R (rs17782313) | TT (30 to 42.9) TC (35 to 50.0) CC (5 to 7.1) | Elevated risk (40, 57.1) | Greater snacking/eating frequency |
Bolded genotypes indicate those included in the ‘elevated risk’ or ‘enhanced response’ categories.
n=70.
MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; SFA, saturated fatty acids.