Table 1

Study demographics according to haptoglobin genotype (mean and SD or median (25th to 75th percentile)

VariableHp1-1 (N=473)Hp2-1 (N=1506)Hp2-2 (N=1197)P value*
Age (years)62.5 (10.8)62.8 (10.6)62.8 (10.7)0.851
Female sex (%)29.630.130.40.947
BMI (kg/m2)27.5 (4.14)27.4 (3.97)27.6 (4.2)0.630
Total-C (mg/dL)193 (40.8)191 (38.1)193 (39.9)0.522
LDL-C (mg/dL)118 (36.4)116 (33.3)116 (34.7)0.502
HDL-C (mg/dL)38.6 (11)38.3 (10.3)39.2 (11.3)0.078
Apo-A1 (mg/dL)130 (25.4)129 (24.1)130 (26)0.214
Apo-A2 (mg/dL)41.6 (9.21)41.2 (9.17)42.0 (9.89)0.135
Cholesterol efflux (%)86.3 (27)89.4 (27.5)86.3 (26.6)0.006
FC/CE0.371 (0.351–0.397)0.374 (0.352–0.399)0.374 (0.352–0.4)0.531
CETP (µg/mL)1.07 (0.82–1.43)1.07 (0.82–1.43)1.11 (0.861–1.46)0.055
TG (mg/dL)149 (112–201)148 (109–203)145 (108–196)0.864
FGLUC (mg/dL)105 (95.4–119)102 (94–118)101 (92.7–118)0.162
HbA1c (%)6.31 (1.31)6.31 (1.23)6.31 (1.25)0.998
Systolic BP (mm Hg)142 (24.1)141 (23.9)141 (23.1)0.903
Diastolic BP (mm Hg)81.2 (11.8)80.9 (11.4)81.1 (11.3)0.787
eGFR (mL/min/1.73m2)80.8 (21.4)81.5 (19.8)82.2 (20.4)0.413
hsCRP (mg/L)2.71 (1.21–7)3.49 (1.35–8.83)3.54 (1.28–8.59)0.032
IL-6 (mg/L)2.86 (1.68–5.39)3.24 (1.8–6.47)3.29 (1.91–5.93)0.058
SAA (mg/L)4.4 (2.5–8.5)5.3 (2.82–13.4)5.2 (3–12.2)0.002
Fibrinogen (mg/dL)369 (316-438)374 (316-449)380 (325-453)0.065
Leucocytes (/nL)6.7 (5.7–8.1)6.75 (5.6–8.1)6.72 (5.7–8.2)0.638
NT-proBNP (pg/mL)323 (109–940)288 (109–870)307 (104–894)0.914
Haptoglobin (mg/dL)167 (141–198)159 (121–206)126 (89–174)<0.001
GGT (U/L)17 (10–29)17 (10–29)17 (11–29)0.909
GPT (U/L)12 (9–19)13 (9–19)13 (9–19)0.764
α-tocopherol (µmol/L)31.7 (26.8–36.9)31.2 (26.7–37.6)31.6 (27.1–37.9)0.875
α-Tocopherol/cholesterol5.9 (5.18–6.74)5.93 (5.22–6.88)5.95 (5.24–6.85)0.808
γ-tocopherol (µmol/L)1.49 (1.12–2.04)1.47 (1.1–2.02)1.45 (1.08–2.02)0.535
γ-tocopherol/cholesterol0.278 (0.211–0.382)0.278 (0.214–0.372)0.276 (0.209–0.376)0.564
Coronary artery disease (%)74.678.978.10.148
Hypertension (%)70.87372.60.641
Active smoking (%)21.623.623.40.653
Diabetes mellitus (%)38.340.340.50.679
  • *Analysis of variance for continuous variables (non-normally distributed variables were log-transformed before entering analysis) and χ2 test for categorical variables.

  • BMI, body mass index; eGFR, estimated glomerular filtration rate; FGLUC, fasting glucose; GGT, gamma-glutamyl transferase; GPT, glutamic-pyruvate transaminase; HDL, high-density lipoprotein; hsCRP, high-sensitive C reactive protein; IL, interleukin; LDL, low-density lipoprotein; NT-proBNP, N-terminal B-type natriuretic peptide; SAA, serum amyloid A; TG, triglycerides; Total-C, total cholesterol.