Table 3

Associations between neighbourhood variables and BMI, testing interaction with number of risk alleles at selected loci

PinteractionHomozygous low risk
(0 risk alleles)
Heterozygous
(one risk allele)
Homozygous high risk
(two risk alleles)
rs1558902 (FTO)
Fast-food proximity0.067−0.099 (−0.198 to −0.001)−0.148 (−0.238 to −0.059)−0.197 (−0.305 to −0.088)
Availability of PA facilities0.933−0.077 (−0.104 to −0.050)−0.077 (−0.103 to −0.051)−0.076 (−0.104 to −0.049)
rs6567160 (MC4R)
Fast-food proximity0.009−0.096 (−0.188 to −0.003)−0.177 (−0.271 to −0.083)−0.258 (−0.386 to −0.130)
Availability of PA facilities0.606−0.078 (−0.104 to −0.051)−0.075 (−0.102 to −0.049)−0.073 (−0.103 to −0.043)
rs13021737 (TMEM18)
Fast-food proximity0.993−0.135 (−0.226 to −0.043)−0.135 (−0.234 to −0.036)−0.135 (−0.279 to 0.008)
Availability of PA facilities0.076−0.080 (−0.106 to −0.053)−0.071 (−0.098 to −0.043)−0.061 (−0.093 to −0.030)
rs13078960 (CADM2)
Fast-food proximity0.114−0.159 (−0.252 to −0.066)−0.108 (−0.205 to −0.010)−0.056 (−0.192 to 0.081)
Availability of PA facilities0.419−0.076 (−0.102 to −0.049)−0.079 (−0.106 to −0.053)−0.083 (−0.114 to −0.053)
rs10938397 (GNPDA2)
Fast-food proximity0.328−0.115 (−0.215 to −0.015)−0.141 (−0.230 to −0.052)−0.167 (−0.274 to −0.061)
Availability of PA facilities0.694−0.076 (−0.102 to −0.049)−0.077 (−0.103 to −0.051)−0.079 (−0.106 to −0.051)
rs7141420 (NRXN3)
Fast-food proximity0.520−0.152 (−0.257 to −0.048)−0.135 (−0.227 to −0.043)−0.118 (−0.224 to −0.012)
Availability of PA facilities0.125−0.071 (−0.097 to −0.044)−0.077 (−0.102 to −0.051)−0.083 (−0.110 to −0.056)
  • PA, physical activity; SNP, single-nucleotide polymorphism.