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Vitamin B6 and Cardiovascular Disease

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Book cover Water Soluble Vitamins

Part of the book series: Subcellular Biochemistry ((SCBI,volume 56))

Abstract

While overt vitamin B6 deficiency is not a frequent finding nowadays in medical practice, evidence suggests that insufficiency of this vitamin is rather widespread in a quite large portion of the population such as the elderly or in not unusual conditions such as that of alcohol addiction. Moreover, a mild deficiency in B6 vitamin is a state that may be associated with an increased risk of cardiovascular disease. Epidemiologic evidence from case control and prospective studies have suggested that low dietary intake or reduced blood concentrations of vitamin B6 is associated with an increased risk of cardiovascular disease, although most recent trials demonstrated the ineffectiveness of vitamin B6 supplementation on the prevention of cardiovascular events recurrence. Due to limited and somewhat inconsistent data together with the ample variety of critical functions in which vitamin B6 is involved in the human body, it is very challenging to attempt at establishing a cause and effect relationship between vitamin B6 and risk of cardiovascular disease as it is to delineate the exact mechanism(s) by which vitamin B6 may modulate such risk. In the present chapter we review the currently available knowledge deriving from both epidemiological and mechanistic studies designed to define potential candidate mechanisms for the association of vitamin B6 impairment and risk of cardiovascular disease development.

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Abbreviations

CAD:

coronary artery disease

CHD:

coronary heart disease

CI:

confidence interval

MI:

myocardial infarction

OR:

odds ratio

PLP:

pyridoxal-5′-phosphate

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Authors and Affiliations

  1. Tufts University, Medford/Somerville, MA, USA

    Simonetta Friso, V. Lotto, R. Corrocher & Sang Woon Choi

  2. Department of Medicine, University of Verona School of Medicine, 37134, Verona, Italy

    Simonetta Friso

  3. Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy

    V. Lotto, R. Corrocher & Sang Woon Choi

  4. Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA HNRCA, Tufts University, Boston, MA, 02111-1524, USA

    Sang Woon Choi

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  1. Simonetta Friso
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  2. V. Lotto
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  3. R. Corrocher
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  4. Sang Woon Choi
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Correspondence to Simonetta Friso .

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  1. Imperial College of Science, Technology and Medicine, Royal Brompton & Harefield NHS Foundatio, Sydney Street, London, SW3 6NP, United Kingdom

    Olaf Stanger

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Friso, S., Lotto, V., Corrocher, R., Choi, S.W. (2012). Vitamin B6 and Cardiovascular Disease. In: Stanger, O. (eds) Water Soluble Vitamins. Subcellular Biochemistry, vol 56. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2199-9_14

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