Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides*
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Cited by (155)
Oxidative stress markers in preeclamptic placentas: A systematic review with meta-analysis
2020, PlacentaCitation Excerpt :However there are discrepancies. Some studies detected increased concentrations in the placentas [26,37,54,60], and in others decreased concentrations [20,23,24,26,30–32,36–38,41,42,46,52,55,57,59–61]. As for the non-enzymatic antioxidant defense system, the GSH, one of the main antioxidants present in the human body, needs to be highlighted.
Review: Maternal and placental antioxidant response to preeclampsia - Impact on vasoactive eicosanoids
2014, PlacentaCitation Excerpt :Interestingly, this model of spontaneous PE displayed impaired placentation and SOD-1 deficiency before the onset of higher blood pressure and proteinuria, which suggests an important role of SOD-1 in the early stages of PE pathogenesis [29]. GPx deficiency is likely the second key player in the etiology of PE, since decreases in this activity can be associated with the synthesis of vasoconstrictive eicosanoids such as F2-isoprostanes and thromboxanes, which are known to be upregulated in PE placentas [30]. Moreover, since GPx are selenoproteins, their synthesis/activity is bound to selenium bioavailability.
Selenium in reproductive health
2012, American Journal of Obstetrics and GynecologyThe possible role of AhR in the protective effects of cigarette smoke on preeclampsia
2011, Medical HypothesesSelenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy
2015, British Journal of Nutrition
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Supported in part by grant no. HD 20973 from the National Institute of Child Health and Human Development and by grant no. VA 92-G-26 from the American Heart Association, Virginia Affiliate. Presented at the Fortieth Annual Meeting of the Society for Gynecologic Investigation, Toronto, Ontario, Canada, March 31–April 3, 1993.
- a
From the Departments of Obstetrics and Gynecology, Medical College of Virginia, Virginia Commonwealth University.
- b
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University.