Benefits of the Mediterranean Diet: Insights From the PREDIMED Study
Section snippets
Scientific evidence of the cardio-metabolic benefits of the Mediterranean diet
The abundant and consistent observational evidence that was available to support the benefits of the Mediterranean diet (MeDiet) and, specifically, of tree nuts and olive oil, on CV health prompted us to choose this traditional dietary model enriched with olive oil or nuts as the intervention.13., 14., 15., 16., 17., 18., 19., 20., 21., 22., 23., 24., 25., 26., 27., 28., 29., 30., 31., 32., 33., 34., 35., 36., 37., 38., 39., 40., 41., 42., 43., 44.Table 1 summarizes the results of meta-analyses
Conclusions
The findings from the PREDIMED trial, the Lyon Diet-Heart trial, and many large prospective cohorts are fully consistent. These large observational and experimental studies are also supported by mechanistic investigations aimed to assess classical and emergent CVD risk factors and pathophysiological pathways. Anti-inflammatory effects and reduced oxidative stress are very likely explanations for the protection observed in the PREDIMED trial. Taken together, these research findings converge,
Statement of conflict of interest
MA Martinez-Gonzalez received grants for research from the International Nut Council, Reus, Spain; J. Salas-Salvado has received grants for research from the International Nut Council, Reus, Spain and is a non paid member of its Scientific Advisory Committee; Ramon Estruch no conflicts of interest; D. Corella no conflicts of interest; M. Fito no conflicts of interest and E. Ros has received grants for research from the California Walnut Commission, Sacramento, CA, U.S. and is a non paid member
Acknowledgments
All authors have read and approved the final manuscript. CIBERobn is an initiative of ISCIII, Spain.
Funding disclosure: Supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140, to Dr. Estruch; RTIC RD 06/0045, to Dr. Martínez-González) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y
References (109)
- et al.
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Lancet
(2012) - et al.
Healthy lifestyle in the primordial prevention of cardiovascular disease among young women
J Am Coll Cardiol
(2015) - et al.
Understanding nutritional epidemiology and its role in policy
Adv Nutr
(2015) - et al.
The Mediterranean diet, its components, and cardiovascular disease
Am J Med
(2015) - et al.
The effect of Mediterranean diet on the development of type 2 diabetes mellitus: a meta-analysis of 10 prospective studies and 136,846 participants
Metabolism
(2014) - et al.
Mediterranean diet and cardiovascular health: teachings of the PREDIMED study
Adv Nutr
(2014) - et al.
Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials
Nutr Metab Cardiovasc Dis
(2014) - et al.
The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals
J Am Coll Cardiol
(2011) - et al.
Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
Am J Clin Nutr
(2010) - et al.
Prevention and control of type 2 diabetes by Mediterranean diet: a systematic review
Diabetes Res Clin Pract
(2010)
The role of Mediterranean type of diet on the development of cancer and cardiovascular disease, in the elderly: a systematic review
Maturitas
A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women
J Nutr
A large randomized individual and group intervention conducted by registered dieticians increased the adherence to Mediterranean-type diets: the PREDIMED study
J Am Diet Assoc
Carotid intima-media thickness changes with Mediterranean diet: a randomized trial (PREDIMED-NAVARRA)
Atherosclerosis
Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study
Free Radic Biol Med
A provegetarian food pattern and reduction in total mortality in the Prevención con Dieta Mediterránea (PREDIMED) study
Am J Clin Nutr
Dietary intake of vitamin K is inversely associated with mortality risk
J Nutr
Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study
Nutr Metab Cardiovasc Dis
Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk
J Nutr
Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk the PREDIMED study
Nutr Metab Cardiovasc Dis
Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the PREDIMED trial
Nutr Metab Cardiovasc Dis
Cross-sectional associations between macronutrient intake and chronic kidney disease in a population at high cardiovascular risk
Clin Nutr
Dietary glycemic index/load and peripheral adipokines and inflammatory markers in elderly subjects at high cardiovascular risk
Nutr Metab Cardiovasc Dis
Association between a healthy lifestyle and general obesity and abdominal obesity in an elderly population at high cardiovascular risk
Prev Med
Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study
Am J Clin Nutr
Association between red meat consumption and metabolic syndrome in a Mediterranean population at high cardiovascular risk cross-sectional and 1-year follow-up assessment
Nutr Metab Cardiovasc Dis
Eating competence of elderly Spanish adults is associated with a healthy diet and a favorable cardiovascular disease risk profile
J Nutr
Cross-sectional association of nut intake with adiposity in a Mediterranean population
Nutr Metab Cardiovasc Dis
Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial
Nutr Metab Cardiovasc Dis
Alcohol consumption is associated with high concentrations of urinary hydroxytyrosol
Am J Clin Nutr
Carotid intima-media thickness is inversely associated with olive oil consumption
Atherosclerosis
Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk
Atherosclerosis
Projections of global mortality and burden of disease from 2002 to 2030
PLoS Med
Global cardiovascular health promotion and disease prevention: 2011 and beyond
Circulation
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond
Circulation
Lifestyle-based prediction model for the prevention of CVD: the Healthy Heart Score
J Am Heart Assoc
Components of a cardioprotective diet: new insights
Circulation
Nutrition and cardiovascular disease
Dietary pattern analysis: a new direction in nutritional epidemiology
Curr Opin Lipidol
Are some diets "mass murder"?
BMJ
Cohort profile: design and methods of the PREDIMED study
Int J Epidemiol
Effectiveness of interventions applicable to primary health care settings to promote Mediterranean diet or healthy eating adherence in adults: a systematic review
Prev Med
Adherence to a Mediterranean diet and risk of diabetes: a systematic review and meta-analysis
Public Health Nutr
Ischemic heart disease and the Mediterranean diet
Curr Cardiol Rep
Mediterranean diet and diabetes: prevention and treatment
Nutrients
Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score
Public Health Nutr
Dietary patterns, Mediterranean diet, and cardiovascular disease
Curr Opin Lipidol
Mediterranean diet and type 2 diabetes
Diabetes Metab Res Rev
Mediterranean diet and cardiovascular risk factors: a systematic review
Crit Rev Food Sci Nutr
Mediterranean diet and metabolic syndrome: an updated systematic review
Rev Endocr Metab Disord
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Statement of Conflict of Interest: see page 56.
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A complete list of PREDIMED INVESTIGATORS can be found at the end of this manuscript.