[HTML][HTML] Effect of diet on the gut microbiota: rethinking intervention duration

ER Leeming, AJ Johnson, TD Spector, CI Le Roy - Nutrients, 2019 - mdpi.com
The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem
implicated in health and disease. The composition of the gut microbiota is unique to each …

[HTML][HTML] Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

KA Lee, AM Thomas, LA Bolte, JR Björk… - Nature medicine, 2022 - nature.com
The composition of the gut microbiome has been associated with clinical responses to
immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific …

[HTML][HTML] The complexities of the diet-microbiome relationship: advances and perspectives

ER Leeming, P Louca, R Gibson, C Menni… - Genome medicine, 2021 - Springer
Personalised dietary modulation of the gut microbiota may be key to disease management.
Current investigations provide a broad understanding of the impact of diet on the …

[HTML][HTML] Diet quality and risk and severity of COVID-19: a prospective cohort study

J Merino, AD Joshi, LH Nguyen, ER Leeming, M Mazidi… - Gut, 2021 - gut.bmj.com
Objective Poor metabolic health and unhealthy lifestyle factors have been associated with
risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the …

[HTML][HTML] Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app

P Louca, B Murray, K Klaser, MS Graham… - … nutrition, prevention & …, 2021 - ncbi.nlm.nih.gov
Objectives Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific
evidence to support such a role is lacking. We investigated whether users of the COVID-19 …

Blue poo: impact of gut transit time on the gut microbiome using a novel marker

F Asnicar, ER Leeming, E Dimidi, M Mazidi, PW Franks… - Gut, 2021 - gut.bmj.com
Background and aims Gut transit time is a key modulator of host–microbiome interactions,
yet this is often overlooked, partly because reliable methods are typically expensive or …

[HTML][HTML] Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome

CI Le Roy, A Kurilshikov, ER Leeming, A Visconti… - BMC microbiology, 2022 - Springer
Background Yoghurt contains live bacteria that could contribute via modulation of the gut
microbiota to its reported beneficial effects such as reduced body weight gain and lower …

[HTML][HTML] High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

C Menni, P Louca, SE Berry, A Vijay, S Astbury… - BMC medicine, 2021 - Springer
Background Chronic inflammation, which can be modulated by diet, is linked to high white
blood cell counts and correlates with higher cardiometabolic risk and risk of more severe …

Effect of whole foods and dietary patterns on markers of subclinical inflammation in weight-stable overweight and obese adults: a systematic review

SF Cowan, ER Leeming, A Sinclair… - Nutrition …, 2020 - academic.oup.com
Context Reduction of subclinical inflammation is a potential target for chronic disease
management. Adiposity is a known modifier of meta-inflammation; however, the influence of …

Association of a Mediterranean diet with outcomes for patients treated with immune checkpoint blockade for advanced melanoma

LA Bolte, KA Lee, JR Björk, ER Leeming… - JAMA …, 2023 - jamanetwork.com
Importance Immune checkpoint blockade (ICB) has improved the survival of patients with
advanced melanoma. Durable responses are observed for 40% to 60% of patients …