User profiles for "author:Fotios Drenos"

Fotios Drenos

Verified email at brunel.ac.uk
Cited by 9784

Mendelian randomization of blood lipids for coronary heart disease

MV Holmes, FW Asselbergs, TM Palmer… - European heart …, 2015 - academic.oup.com
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for …

[HTML][HTML] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

DI Swerdlow, D Preiss, KB Kuchenbaecker… - The Lancet, 2015 - thelancet.com
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …

[HTML][HTML] Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control …

PJ Talmud, S Shah, R Whittall, M Futema, P Howard… - The Lancet, 2013 - thelancet.com
Background Familial hypercholesterolaemia is a common autosomal-dominant disorder
caused by mutations in three known genes. DNA-based cascade testing is recommended by …

Rare and low-frequency coding variants alter human adult height

E Marouli, M Graff, C Medina-Gomez, KS Lo, AR Wood… - Nature, 2017 - nature.com
Height is a highly heritable, classic polygenic trait with approximately 700 common
associated variants identified through genome-wide association studies so far. Here, we …

Role of β adrenergic receptor polymorphisms in heart failure: Systematic review and meta‐analysis

A Muthumala, F Drenos, PM Elliott… - European journal of …, 2008 - Wiley Online Library
Heart Failure (HF) is a common disorder associated with substantial morbidity and mortality.
β adrenergic receptors (βAR) are the primary pathway through which cardiac function is …

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

GB Ehret, T Ferreira, DI Chasman, AU Jackson… - Nature …, 2016 - nature.com
To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

P Surendran, F Drenos, R Young, H Warren, JP Cook… - Nature …, 2016 - nature.com
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …

[PDF][PDF] Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

R Saxena, CC Elbers, Y Guo, I Peter, TR Gaunt… - The American Journal of …, 2012 - cell.com
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

V Turcot, Y Lu, HM Highland, C Schurmann… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …