Introduction With a worldwide ageing population, the importance of the prevention and
management of osteoporotic fragility fractures is increasing over time. In this review, we …

The coexistence of osteoporosis and sarcopenia has been recently considered in some
groups as a syndrome termed 'osteosarcopenia'. Osteoporosis describes low bone mass …

Despite substantial advances in delineation of the epidemiology, pathophysiology, risk
assessment and treatment of osteoporosis over the last three decades, a substantial …

Background We consider the relationships between a clinical and radiological diagnosis of
knee or hip OA and activities of daily-living (ADL) in older adults. Methods Data were …

In a global survey of fracture liaison services, most reported that DXA access met needs.
However, adherence to basic DXA quality and reporting procedures was confirmed by only …

Reactive arthritis (ReA) is an inflammatory spondyloarthritis occurring after infection at a
distant site. Chlamydia trachomatis is proposed to be the most common cause of ReA, yet …

Objective Epidemiological studies of knee osteoarthritis (OA) have often used a radiographic
definition. However, the clinical syndrome of OA is influenced by a broad range of factors in …

Objectives: Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease which
presents with polyarthritis in addition to extra-articular manifestations. Historically, studies …

Adenylyl cyclases (ACs) are a family of critically important signaling molecules that are
regulated by multiple pathways. Adenylyl cyclase 8 (AC8) is a Ca2+ stimulated isoform that …

Multiply regulated adenylyl cyclases (AC) and phosphodiesterases (PDE) can yield complex
intracellular cAMP signals. Ca2+-sensitive ACs have received far greater attention than the …