[HTML][HTML] Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

A Choudhury, JT Brandenburg, T Chikowore… - Nature …, 2022 - nature.com
Genetic associations for lipid traits have identified hundreds of variants with clear differences
across European, Asian and African studies. Based on a sub-Saharan-African GWAS for …

[HTML][HTML] Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans

PR Boua, JT Brandenburg, A Choudhury… - Nature …, 2022 - nature.com
Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases
(CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility …

[HTML][HTML] Apolipoprotein L1 high-risk genotypes and albuminuria in sub-Saharan African populations

JT Brandenburg, MA Govender… - Clinical Journal of the …, 2022 - journals.lww.com
Results High G1 allele frequencies occurred in South and West Africa (approximately 7%–
13%). G2 allele frequencies were highest in South Africa (15%–24%), followed by West …

[HTML][HTML] Prevalence and socio-demographic correlates of tobacco and alcohol use in four sub-Saharan African countries: a cross-sectional study of middle-aged …

PR Boua, CC Soo, C Debpuur, I Maposa, S Nkoana… - BMC Public Health, 2021 - Springer
Background Substance misuse is a global public health problem. In addition to social and
economic concerns, consumption of tobacco and alcohol is associated with susceptibility to …

[HTML][HTML] The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey

M Lingani, T Akita, S Ouoba, S Nagashima… - BMC Infectious …, 2020 - Springer
Background This study sought to provide up-to-date hepatitis B (HBV) and C (HCV)
seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the …

[HTML][HTML] Novel and known gene-smoking interactions with cIMT identified as potential drivers for atherosclerosis risk in West-African populations of the AWI-Gen study

PR Boua, JT Brandenburg, A Choudhury… - Frontiers in …, 2020 - frontiersin.org
Introduction Atherosclerosis is a key contributor to the burden of cardiovascular diseases
(CVDs) and many epidemiological studies have reported on the effect of smoking on carotid …

Undernutrition in children aged 0–59 months by region and over time: secondary analysis of the Burkina Faso 2012–2018 National Nutrition Surveys

PR Boua, T Rouamba, E Bambara, S Kaboré… - BMJ open, 2023 - bmjopen.bmj.com
The global burden of undernutrition remains high, responsible for significant under-five
mortality in resource-limited settings. Numerous sustainable development goals (SDGs) are …

Genetically predicted lipid traits, diabetes liability, and carotid intima-media thickness in African ancestry individuals: a mendelian randomization study

O Soremekun, EAW Slob, S Burgess… - Circulation: Genomic …, 2022 - Am Heart Assoc
Carotid intima-media thickness (cIMT) is a measure of atherosclerosis used to predict
cardiovascular disease. 1 Lipid traits and type 2 diabetes (T2D) have been implicated in the …

Genetic Association and Transferability for Urinary Albumin-Creatinine Ratio as a Marker of Kidney Disease in four Sub-Saharan African Populations and non …

JT Brandenburg, WC Chen, PR Boua, MA Govender… - medRxiv, 2024 - medrxiv.org
Background Genome-wide association studies (GWAS) have predominantly focused on
populations of European and Asian ancestry, limiting our understanding of genetic factors …

[HTML][HTML] Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK

NN Piga, PR Boua, C Soremekun, N Shrine, K Coley… - Scientific reports, 2022 - nature.com
Smoking is a leading risk factor for many of the top ten causes of death worldwide. Of the 1.3
billion smokers globally, 80% live in low-and middle-income countries, where the number of …