User profiles for "author:Peter Jones"

Peter A. Jones

Chief Scientific Officer, Van Andel Institute
Verified email at vai.org
Cited by 113715

Cancer-epigenetics comes of age

PA Jones, PW Laird - Nature genetics, 1999 - nature.com
The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

The fundamental role of epigenetic events in cancer

PA Jones, SB Baylin - Nature reviews genetics, 2002 - nature.com
Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Functions of DNA methylation: islands, start sites, gene bodies and beyond

PA Jones - Nature reviews genetics, 2012 - nature.com
DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

Very high resolution interpolated climate surfaces for global land areas

RJ Hijmans, SE Cameron, JL Parra… - … of Climatology: A …, 2005 - Wiley Online Library
We developed interpolated climate surfaces for global land areas (excluding Antarctica) at a
spatial resolution of 30 arc s (often referred to as 1‐km spatial resolution). The climate …

[HTML][HTML] The epigenomics of cancer

PA Jones, SB Baylin - Cell, 2007 - cell.com
Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

Epigenetics in human disease and prospects for epigenetic therapy

G Egger, G Liang, A Aparicio, PA Jones - Nature, 2004 - nature.com
Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

PL Jones, GJC Veenstra, PA Wade, D Vermaak… - Nature …, 1998 - nature.com
CpG methylation in vertebrates correlates with alterations in chromatin structure and gene
silencing 1, 2, 3, 4. Differences in DNA-methylation status are associated with imprinting …

Epigenetics in cancer

S Sharma, TK Kelly, PA Jones - Carcinogenesis, 2010 - academic.oup.com
Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

A decade of exploring the cancer epigenome—biological and translational implications

SB Baylin, PA Jones - Nature Reviews Cancer, 2011 - nature.com
The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …

Replacing the complementarity-determining regions in a human antibody with those from a mouse

PT Jones, PH Dear, J Foote, MS Neuberger, G Winter - Nature, 1986 - nature.com
The variable domains of an antibody consist of a β-sheet framework with hypervariable
regions (or complementarity-determining regions—CDRs) which fashion the antigen …