[HTML][HTML] Antibody-drug conjugates for cancer therapy: chemistry to clinical implications
Chemotherapy is one of the major therapeutic options for cancer treatment. Chemotherapy
is often associated with a low therapeutic window due to its poor specificity towards tumor …
is often associated with a low therapeutic window due to its poor specificity towards tumor …
[HTML][HTML] Smoking and COVID-19: adding fuel to the flame
VK Kashyap, A Dhasmana, A Massey… - International journal of …, 2020 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, an infection caused by the severe
acute respiratory syndrome coronavirus (SARS-CoV-2), has led to more than 771,000 …
acute respiratory syndrome coronavirus (SARS-CoV-2), has led to more than 771,000 …
Microbiome based approaches for the degradation of polycyclic aromatic hydrocarbons (PAHs): A current perception
Globally, polycyclic aromatic hydrocarbons (PAHs) pollution is primarily driven by their
release into the air through various combustion processes, including burning fossil fuels …
release into the air through various combustion processes, including burning fossil fuels …
[HTML][HTML] Tannic acid induces endoplasmic reticulum stress-mediated apoptosis in prostate cancer
Endoplasmic reticulum (ER) stress is an intriguing target with significant clinical importance
in chemotherapy. Interference with ER functions can lead to the accumulation of unfolded …
in chemotherapy. Interference with ER functions can lead to the accumulation of unfolded …
[HTML][HTML] Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics
VK Kashyap, G Peasah-Darkwah, A Dhasmana… - Pharmaceutics, 2022 - mdpi.com
Chemotherapy is one of the prime treatment options for cancer. However, the key issues
with traditional chemotherapy are recurrence of cancer, development of resistance to …
with traditional chemotherapy are recurrence of cancer, development of resistance to …
[HTML][HTML] Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells
Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their
survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation …
survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation …
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M …
Abstract The mycobacterial F 0 F 1-ATP synthase (ATPase) is a validated target for the
development of tuberculosis (TB) therapeutics. Therefore, a series of eighteen novel …
development of tuberculosis (TB) therapeutics. Therefore, a series of eighteen novel …
[HTML][HTML] miRNA-205 nanoformulation sensitizes prostate cancer cells to chemotherapy
The therapeutic application of microRNA (s) in the field of cancer has generated significant
attention in research. Previous studies have shown that miR-205 negatively regulates …
attention in research. Previous studies have shown that miR-205 negatively regulates …
Ormeloxifene suppresses prostate tumor growth and metastatic phenotypes via inhibition of oncogenic β-catenin signaling and EMT progression
Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also
shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore …
shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore …
Withania somnifera as a potential future drug molecule for COVID-19
Conclusion Together, the literature strongly suggests that derivatives of W. somnifera can
bind to the key targets (Spike protein, ACE-2, RdRp, 3CLpro and PLpro) of SARS-CoV-2 …
bind to the key targets (Spike protein, ACE-2, RdRp, 3CLpro and PLpro) of SARS-CoV-2 …