Supplementation with selenium and human immune cell functions: I. Effect on lymphocyte proliferation and interleukin 2 receptor expression
M Roy, L Kiremidjian-Schumacher, HI Wishe… - Biological trace element …, 1994 - Springer
M Roy, L Kiremidjian-Schumacher, HI Wishe, MW Cohen, G Stotzky
Biological trace element research, 1994•SpringerSelenium (Se) is an essential nutritional factor that was shown by us to alter the expression
of the high affinity interleukin 2 receptor (I l 2-R) and its subunits, cell proliferation, and clonal
expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation
of Se-replete humans with 200 μg/d of sodium selenite for 8 wk, or in vitro supplementation
with 1× 10− 7 M Se (as sodium selenite), result in a significant augmentation of the ability of
peripheral blood lymphocytes to respond to stimulation with 1 μg/mL of phytohemagglutinin …
of the high affinity interleukin 2 receptor (I l 2-R) and its subunits, cell proliferation, and clonal
expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation
of Se-replete humans with 200 μg/d of sodium selenite for 8 wk, or in vitro supplementation
with 1× 10− 7 M Se (as sodium selenite), result in a significant augmentation of the ability of
peripheral blood lymphocytes to respond to stimulation with 1 μg/mL of phytohemagglutinin …
Abstract
Selenium (Se) is an essential nutritional factor that was shown by us to alter the expression of the high affinity interleukin 2 receptor (Il 2-R) and its subunits, cell proliferation, and clonal expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation of Se-replete humans with 200 μg/d of sodium selenite for 8 wk, or in vitro supplementation with 1×10−7 M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 μg/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il 2-R on their surface. There was a clear correlation between supplementation with Se and enhanced3H-thymidine incorporation into nuclear DNA, preceded by enhanced expression of high affinity Il 2-R. Supplementation with Se can apparently modulate T-lymphocyte mediated immune responses in humans that depend on signals generated by the interaction of interleukin 2 with Il 2-R.
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