BACKGROUND Nonnutritive sweeteners, such as aspartame, sucralose and stevioside, are
widely consumed, yet their long-term health impact is uncertain. We synthesized evidence …

OBJECTIVE: To synthesize evidence from prospective studies evaluating the association of
early-life NNS exposure and long-term metabolic health. DATA SOURCES: Medline, Embase…

Stroke is the leading cause of death in many countries of Latin America. Population studies
are necessary in this region. Objectives: To evaluate the prevalence of stroke and its risk …

Background In view of many unanswered clinical questions regarding treatment of COVID-19
with remdesivir, we systematically identified, critically appraised and summarized the …

Background To better inform clinical practice, we summarized the findings from randomized
controlled trials (RCTs) of antivirals for COVID-19. Methods We systematically searched for …

Objectives To provide a comprehensive systematic overview of current evidence from
pooled analyses/meta-analyses and systematic reviews (PMASRs) pertaining to dairy …

Background Delays in reperfusion for patients with myocardial ischemia leads to increased
morbidity and mortality. The objective of this review was to identify, evaluate, and critically …

Background A new tool, “risk of bias (ROB) instrument for non-randomized studies of
exposures (ROB-NRSE),” was recently developed. It is important to establish consistency in its …

Objectives To identify, critically appraise and summarise evidence on the impact of employing
primary healthcare professionals (PHCPs: family physicians/general practitioners (GPs), …

Objectives To conduct a scoping review to identify and summarise the existing literature on
interventions involving primary healthcare professionals to manage emergency department (…